Download E-books Next-Generation DNA Sequencing Informatics, Second Edition PDF

By Stuart M. Brown

Next-generation DNA sequencing (NGS) expertise has revolutionized biomedical study, making genome and RNA sequencing an inexpensive and often used instrument for a wide selection of analysis functions together with variation (mutation) discovery, gene expression, transcription issue research, metagenomics, and epigenetics. Bioinformatics ways to aid DNA sequencing became and stay a serious bottleneck for plenty of researchers and organisations wishing to use NGS expertise. This new version offers a radical, plain-language creation to the mandatory informatics tools and instruments for reading NGS info and gives particular descriptions of algorithms, strengths and weaknesses of particular instruments, pitfalls, and replacement equipment. 4 new chapters conceal experimental layout, pattern guidance, and caliber overview of NGS information; public databases for DNA sequencing information; de novo transcript meeting; proteogenomics; and rising sequencing applied sciences. the remainder chapters from the 1st variation were up to date with the most recent details. This booklet additionally presents vast connection with best-practice bioinformatics equipment for NGS functions and tutorials for universal workflows. This variation addresses the informatics wishes of scholars, laboratory scientists, and computing experts who desire to make the most of the explosion of analysis possibilities provided by means of new DNA sequencing technologies.

Authors

Alexander Alekseyenko
Silvia Argimón
Brian D. Athey
Miroslav Blumenberg
Stuart M. Brown
Lisa Cohen
Efstratios Efstathiadis
David Fenyö
Jeremy Goecks
Gerald A. Higgins
D. Frank Hsu
Kranti Konganti
Konstantinos Krampis
Guillermo I. Perez-Perez
Kelly V. Ruggles
Christina Schweikert
Steven Shen
Phillip Ross Smith
Zuojian Tang
Jinhua Wang

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